Promising New Treatment for

Multiple Sclerosis with Stem Cells

Promising New Treatment for Multiple Sclerosis with Stem Cells

Current drugs and medications for Multiple Sclerosis (MS) such as Prednisone, Baclofen, Interferon Beta, Glatiramer Acetate and Natalizumab are administered to slow down the progression of Multiple Sclerosis and reduce its symptoms. These drugs are known to suppress the immune responses that are caused by MS. The reversal of (already appeared) symptoms and preventing the disease's progression is rarely achieved.

As such, stem cell-based therapies have recently emerged as a promising novel medication for treating MS, because, next to the beneficial effects of stem cells on the immune system, stem cells were shown to stimulate regeneration of the neurological damages that are induced by MS. Therefore stem cell-based therapies are an excellent choice to treat the disease.

Stem Cell-based Treatment for Multiple Sclerosis

MS graficFigure 1: Healthy neuron vs. neuron affected by Multiple Sclerosis.

Multiple Sclerosis is caused by a misguided autoimmune response (attack) against the “myelin sheath” of nerve cells. The muelin sheath is much like an insulation layer of a cable, to electrically insulate the nerve, thus protecting it to ensure the proper functioning of the nervous system (see Fig. 1).

Damage or degeneration of the protective layer (myelin sheath) will lead to impairments to the normal function of the affected nerves. The severity of impairments varies among individuals.

Stem cells appear to have two major beneficial effects for treating this severe autoimmune neurodegenerative disease, as they can:

1) Repair damaged nerves (remyelination)
2) Modify the effects of the immune system, such as protection from further attacks on the myelin sheaths (neuroprotection).

Treating MS patients with stem cell-based therapies has already been conducted with much success.

The promising results from these phase I/II studies have shown to:

               * reduce inflammation immediately

               * improve visual acuity and
                evoke improved response latency

               * increase of optic nerve area

               * inhibition of new lesion development
               and reduction of lesion areas

               * fewer incidences of relapse as compared to
               patients who received anti-inflammatory
               and immunosuppression treatments only

And most importantly, until now, no side effects have been noted in treating MS patients with stem cells.

The scientific breakthroughs in treating MS has inspired our scientists to develop a novel therapy for treating patients with MS. We use the highest concentration of paracrine factors (the Stem Cell Secretome) to deliver the most optimized medication to date, for treating patients with MS.

According to the regenerative effects of Mesenchymal Stem Cells on the nervous and immune system, all types of Multiple Sclerosis can be treated effectively, such as: Relapsing Remitting MS (RRMS), Primary Progressive MS (PPMS) and Secondary Progressive MS (SPMS).

To find out more about ANOVA's Stem Cell-based Multiple Sclerosis treatment plans and guidelines, please click here to contact us.

Stem Cell-based Treatment for Multiple Sclerosis: Assurance of a High Quality Treatment

ANOVA uses the latest results from stem cell research to produce and combine the safest and most efficient stem cell therapies. 

Furthermore, we have developed and applied standardized procedures for stem cell isolation and processing, as well as for the diagnosis and treatment of MS. This includes, amongst others, the use Magnetic Resonance Imaging (MRI) to diagnose MS, coupled with special blood tests. In addition to our advanced diagnostics, we objectively track the therapeutic success of the stem cell-based treatment after its administration. This way we strive to provide you with the best personalized stem cell-based therapy for treatment of MS.

To find out more about our quality control system and the standardized stem cell-based procedures for the treatment of Multiple Sclerosis, please click here to contact us.

Why using stem cells for Multiple Sclerosis - The Scientific Background:

Figure 1Figure 2: the body's own immune cells destroy myelin in Multiple Sclerosis

"Multiple sclerosis is caused by the destruction of the myelin sheath of nerve cells, which can be reconstructed by stem cells”.

In the past decade, stem cell research has revealed a great potential of utilizing Mesenchymal Stem Cells (MSCs) to reduce inflammation and beneficially modulate the immune system. Interestingly, apart from the immunosuppressive abilities, Mesenchymal Stem Cells were shown to stimulate the regeneration of a variety of damaged tissues.

Multiple Scleroris is manifested by the destruction of the myelin sheath, which is caused by auto-attacks on the myelin sheaths, due to a disorder in the immune system (see Fig. 1 and Fig. 2). As such, stem cell-based treatments are a promising candidate in slowing down the progression of Multiple Sclerosis. Due to their interaction with the immune system and being able to regenerate damaged areas, they are able to alleviate the symptoms of MS for long periods of time.

The so-called paracrine activity of stem cells has been characterized by the induction of positive and regenerative effects on damaged tissue and neurons. The paracrine action is described by the production of important factors that are secreted by cells, for efficient communication between surrounding cells and tissues. Regarding the last point, stem cells themselves have been shown to produce such factors; to initiate communication pathways with the damaged cells and tissues to trigger their regeneration (see Fig. 2). The regenerative factors are composed of growth factors, cytokines and cell cycle regulating miRNAs. They are packed in lipid shells (exosomes and microvesicles) for the transport of information.

Next to the regenerative capabilities of stem cells, especially Mesenchymal Stem Cells like adipose tissue derived stem cells (ASC), bone marrow derived stem cells (BMSC) and umbilical cord blood stem cells (UCBSC), have been shown to communicate with the immune system as well, resulting in immediate reduction of inflammation and initiating other beneficial effects.

Rest assured, new scientific data is constantly emerging; further confirming and elaborating upon the benefits of stem cell-based treatments for neurodegenerative and autoimmune diseases. For more detailed information about the current stem cell research, please click here.

Scientists and physicians are seeing a great potential of stem cells to significantly ameliorate the symptoms MS and to slow down the progression of the disease. One day in the future, it may be possible to completely stop MS from progressing and perhaps even curing the disease.

If you have any questions regarding our stem cell-based treatments for MS, please feel free to contact us or apply for a treatment here.

References and Literature -  (Click for more)

If you are interested to receive the list of references, please contact us.

References and Literature - Stem Cell-based Therapies for Multiple Sclerosis (Click for more)

[1] Fox, R. J. & Ransohoff, R. M. New directions in MS therapeutics: vehicles of hope. Trends Immunol. 2004; 25(12):632-6.
[2] Caplan, A. I. Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. J Cell Physiol. 2007; 213(2):341-7.
[3] Gianvito Martino, Robin J. M. Franklin, Anne Baron Van Evercooren, Douglas A. Kerr. Stem cell transplantation in multiple sclerosis: current status and future prospects. Nat. Rev. Neurol. 2010; 6, 247–255.
[4] Trapp, B.D. et al. Axonal transection in the lesions of multiple sclerosis. N. Engl. J. Med. 1998; 338, 278–285
[5] Freedman MS, Bar-Or A, Atkins HL, Karussis D, Frassoni F, Lazarus H, Scolding N, Slavin S, Le Blanc K, Uccelli A; MSCT Study Group. Study Group The therapeutic potential of mesenchymal stem cell transplantation as a treatment for multiple sclerosis: consensus report of the International MSCT Study Group. Multiple Sclerosis. 2010; 16(4) 503–510.
[6] Karussis D, Karageorgiou C, Vaknin-Dembinsky A, Gowda-Kurkalli B, Gomori JM, Kassis I, Bulte JW, Petrou P, Ben-Hur T, Abramsky O, Slavin S. Safety and Immunological Effects of Mesenchymal Stem Cell Transplantation in Patients With Multiple Sclerosis and Amyotrophic Lateral Sclerosis. Arch Neurol. 2010; 67(10):1187-1194.
[7] Connick P1, Kolappan M, Crawley C, Webber DJ, Patani R, Michell AW, Du MQ, Luan SL, Altmann DR, Thompson AJ, Compston A, Scott MA, Miller DH, Chandran S. Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study. Lancet Neurol 2012; 11: 150–56.
[8] Llufriu S, Sepúlveda M, Blanco Y, Marín P, Moreno B, Berenguer J, Gabilondo I, Martínez-Heras E, Sola-Valls N, Arnaiz JA, Andreu EJ, Fernández B, Bullich S, Sánchez-Dalmau B, Graus F, Villoslada P, Saiz A. Randomized Placebo-Controlled Phase II Trial of Autologous Mesenchymal Stem Cells in Multiple Sclerosis. PLoS One. 2014; 1;9(12).
[9] Li JF, Zhang DJ, Geng T, Chen L, Huang H, Yin HL, Zhang YZ, Lou JY, Cao B, Wang YL. The Potential of Human Umbilical Cord-Derived Mesenchymal Stem Cells as a Novel Cellular Therapy for Multiple Sclerosis. Cell Transplant. 2014; 23 Suppl 1:S113-22.
[10] Tyndall A, Walker UA, Cope A, Dazzi F, De Bari C, Fibbe W, Guiducci S, Jones S, Jorgensen C, Le Blanc K, Luyten F, McGonagle D, Martin I, Bocelli-Tyndall C, Pennesi G, Pistoia V, Pitzalis C, Uccelli A, Wulffraat N, Feldmann M. Immunomodulatory properties of mesenchymal stem cells: a review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005. Arthritis Research & Therapy 2007; 9:301
[11] Baraniak PR1, McDevitt TC. Stem cell paracrine actions and tissue regeneration. Regen Med. 2010; 5(1):121-43
[12] Chandran S, Hunt D, Joannides A, Zhao C, Compston A, Franklin RJ. Myelin repair: the role of stem and precursor cells in multiple sclerosis. Philos Trans R Soc Lond B Biol Sci. 2008; 12;363(1489):171-83.
[13] Bollini S, Gentili C, Tasso R, Cancedda R. The Regenerative Role of the Fetal and Adult Stem Cell Secretome. J Clin Med. 2013; 17;2(4):302-27
[14] Yeo RWY, Lai RC, Tan KH Lim SK. Exosome: A Novel and Safer Therapeutic Refinement of Mesenchymal Stem Cell. Exosomes microvesicles. 2013, Vol. 1, 7.

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