Stem Cell Treatment for Spinal Cord Injury (SCI)

Stem Cell Treatment for Spinal Cord Injury (SCI)

stem cells spinal cord injury wide

The spinal cord is a long, fragile, tubelike nervous structure that connects the brain with peripheral nerves. Damage to the spinal cord, by trauma or other disease, consequently results in severe motor- and sensory deficits, that usually leads to the inability to move and feel. Accidents are the most common cause of Spinal Cord Injury (SCI), with catastrophic consequences for the life of the patient and his relatives. While conservative therapies aim to stabilize the patient, functional recovery in most cases is minimal.

Both, preclinical and clinical studies were able to show faster and better recovery of SCI patients when the therapy was combined with a suitable stem cell therapy. With the Anova Stem Cell Secretome | Exosome treatment we provide access to the most advanced clinically available combination of stem cell-based therapies for the treatment of SCI.

Hope for patients with SCI - Therapy with latest German stem cell technology

Nerve crossection SEM An electron microscopy image of a crossection of a spinal nerve, illustrating the complexity on a tiny scale. This is why nerve repair needs to happen on the celullar level with stem cells, as it can not be repaired in any other way. Image from UCSD tumblr

Spinal trauma can disrupt ascending and descending axonal pathways that lead to: inflammation, demyelination and loss of neural cells (neurons). Depending on the site of injury, functional disorders induced by cellular damage usually result in the inability move, sensory loss and/or lack of autonomous nervous system control.

Fully regenerative therapies for spinal trauma do not exist yet. However, very promising results have been obtained with stem cell transplantation in patients with spinal trauma. The use of MSCs in Spinal Cord Injury has been extensively reviewed. Experiments with Mesenchymal Stem Cells (MSCs) have shown that their abilitites to stimulate repair processes in spinal cord injury are due to the paracrine secretion of the stem cells. After 21 days of observations, even though the MSCs had not been incorporated into the regenerated host tissue, there was a significant improvement in functional recovery, from as early as one week after the treatment with MSCs. The progress in this area has recently been reviewed in the scietific paper from Lamichhane and colleagues. With the Anova Stem Cell Secretome, we make a significant first step to bring these novel results to clinical use, and to the patients that need it now.

Give your body a fighting chance to recover –
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With Bone Marrow Concentrate (BMC), and the latest generation of Stem Cell treatments, the Stem Cell Secretome, Anova offers an unique, and highly potent program that synergizes well with your physical rehabilitation recovery. We think we offer the best fighting chance you can currently get, for a quicker recovery and better outcome. Don’t give yourself up. Your stem cells built you in the first place, and they can surely help you to (at least, partially) regenerate you. Get yourself informed of your possibilities to get treated with the best German stem cell-based products. Contact our medical team at Anova to find out which stem cell therapy for spinal cord injury is an ideal treatment option for you.

References and Literature - Stem Cell-based Therapies and Spinal Cord Injuries (Click for more)

[1] A. Hejcl, J. Sedy, M. Kapcalova, D.A. Toro, T. Amemori, P. Lesny, K. Likavcanova-Masinova, E. Krumbholcova, M. Pradny, J. Michalek, M. Burian, M. Hajek, P. Jendelova, E. Sykova, HPMA-RGD hydrogels seeded with mesenchymal stem cells improve functional outcome in chronic spinal cord injury, Stem Cells Dev. 19 (2010) 1535e1546.
[2] Anthony, Diana F., and Paul G. Shiels. "Exploiting paracrine mechanisms of tissue regeneration to repair damaged organs." Transplantation research 2.1 (2013): 10.
[3] Wright KT, Masri WE, Osman A, Chowdhury J, Johnson WEB: Concise review: bone marrow for the tre atment of spinal cord injury: mechanisms and clinical implications. Stem Cells 2011, 29: 169 – 178
[4] Quertainmont R, Cantinieaux D, Bot man O, Eid S, Schoenen J, Franzen R: Mesenchymalstemcellgraftimproves recovery after spinal cord injury in adult rats through neurotrophic and pro-angiogenic actions. PLoS One 2012, 7: e39500.
[5] Lamichhane, Tek N., et al. "Emerging roles for extracellular vesicles in tissue engineering and regenerative medicine." Tissue Engineering Part B: Reviews 21.1 (2014): 45-54.
[6] Thuret, Sandrine, Lawrence DF Moon, and Fred H. Gage. "Therapeutic interventions after spinal cord injury." Nature Reviews Neuroscience 7.8 (2006): 628-643.
[7] Thuret, Sandrine, Lawrence DF Moon, and Fred H. Gage. "Therapeutic interventions after spinal cord injury." Nature Reviews Neuroscience 7.8 (2006): 628-643.
[8] Lindvall O, Kokaia Z: Stem cells for the treatment of neurological disorders. Nature 2006, 441(7097):1094-1096.
[9] Yoon SH, Shim YS, Park YH, Chung JK, Nam JH, Kim MO, Park HC, Park SR, Min BH, Kim EY, et al: Complete spinal cord injury treatment using autologous bone marrow cell transplantation and bone marrow stimulation with granulocyte macrophage-colony stimulating factor: Phase I/II clinical trial. Stem Cells 2007, 25(8):2066-2073.
[10] Karamouzian S, Nematollahi-Mahani SN, Nakhaee N et al (2012) Clinical safety and primary efficacy of bone marrow mesenchymal cell transplantation in subacute spinal cord injured patients. Clin Neurol Neurosurg 114(7):935–939
[11] Saito F, Nakatani T, Iwase M et al (2008) Spinal cord injury treatment with intrathecal autologous bone marrow stromal cell transplantation: the first clinical trial case report. J Trauma 64(1):53–59
[12] Saito F, Nakatani T, Iwase M et al (2012) Administration of cul¬tured autologous bone marrow stromal cells into cerebrospinal fluid in spinal injury patients: a pilot study. Restor Neurol Neu¬rosci 30(2):127–136

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