The Anova IRM Erectile Dysfunction (ED) Program:

Treating ED and Impotence with Stem Cell-based Therapies

The Anova IRM Erectile Dysfunction (ED) Program:
Treating ED and Impotence with Stem Cell-based Therapies

Erectile Dysfunctions (ED) is defined as the reduction of potency and libido. It can have a variety of causes, both physical and psychological. Most frequent reasons are diabetes, smoking, obesity, high blood pressure or as a side effect from a prostate cancer operation. Additionally, the effects of aging are partly responsible for impotence and ED.

All age groups of men can suffer from weak penile erections, which renders their sexual intercourse problematic or even impossible. In the previous decade, the so called “PDE-5 inhibitors” medications were shown to be a successful group of drugs that improved the quality of life of many affected men. However, they offer limited help by temporarily overriding the symptoms of impotence and ED.

Now, with recent advancements in stem cell therapies, a long lasting solution promises a permanent improvement of potency at minimal risks. We are the first to introduce a systematic stem cell-based medical treatment approach to treating impotence and ED.

Please feel free to give us a call for more information on how we treat ED with our cutting-edge stem cell-based therapies.

A cure for Erectile Dysfunction (ED) and Impotency – Medicine is near a breakthrough to naturally target the cause of Erectile Dysfunction (ED) and not only covering the symptoms of ED with medication.

Reduced potency and erectile dysfunction can occur from a wide range of causes. Most commonly, it is age related, but it can also be related to diseases like diabetes and high blood pressure. Other common causes are life style related such as smoking, frequent intake of alcohol or obesity.

Despite the wide range of causes of ED, the common denominator is that until now there were only ways to treat the symptoms. Typical medications to treat Erectile Dysfunction (ED) and impotency are based on a substance group called “PDE-5 inhibitors”. Many other drugs have displayed temporal help against impotence in form of injections or creams. There is no clear answer on which of these ED treatment drugs is the best; as they have different properties and side effects. However, all of these drugs have one thing in common: they do not target the cause and therefore are not a “cure”. Their mode of action is based on temporarily overriding the symptoms of weak or no erections.

Regenerative medicine, and the use stem cells as one of their major tools in treating numerous conditions, allows us for a fundamentally different treatment approach providing us with the chance of curing the problem, at the core, where it begins. All causes of erectile dysfunction, except in the case of psychologically induced impotence, have some form of primary or secondary blood or nerve supply problem as their main cause. Stem cell-based regenerative therapies promote both, angiogenesis (new growth of blood vessels and blood supply improvement) as well as neurotophy / neuroprotection (new growth and protection of nerve supply of the penis).

While there are some causes of ED which cannot be treated (i.e. psychologically induced ED), new discoveries in regenerative medicine and stem cells may be able to find the solution. For the first time, at Anova, we would like to report that regeneration of the blood- and nerve-supply related causes of ED is possible in an natural way without any known side effects.

A new chance for patients suffering from erectile dysfunction (ED) or incontinence after prostate cancer treatments (Prostatectomy or Radiation Therapy)

Stem Cell Treatment For ED After Damage From Prostate Cancer OperationNerve and vessel boundles around the prostate which get's damaged after prostatectomy treatmentviiii

The Prostate is surrounded and party interwoven with a fine mesh of nerves and blood vessels called the neurovascular bundle that are responsible for the control of penile erections. In prostate cancer operations (prostatectomy), and even after radiation therapies, these structures are susceptible to be damaged permanently.

While new cancer treatments like IRE/NanoKnife are on their way to make these radical treatment approaches a clinical relict, currently, they are still the standard method of therapy in most countries. Hence, if you had prostate cancer, you are likely to suffer from incontinence, impotence or both to some extent.

Is there a cure or a treatment for incontinence or impotence after prostatectomy? For both, impotence and incontinence, stem cell-based treatments have shown to be effective and safe in improving the functional outcome We highly recommend that you to get in touch with us. With our close cooperation with the world leading Prostate-Center, we are likely to be able to help you.

Get the best ED treatment: the best doctors, latest diagnostic methods, the best ED drugs and therapies – all combined with the most advanced stem cell based ED treatment program.

Reduction of potency, impotence and erectile dysfunction has a wide range of possible causes. A good medical assessment and diagnostic is absolutely essential before creating a personalized treatment plan for your erectile dysfunction. Seldom will a single injection of random Stem Cells for discount prices adequately address your erectile problems. Anova IRM is a fully equipped image diagnostic clinic with several MRI scanners, CT, ultrasound and state of the art blood test and doctors of many specialties. We will analyse the cause of your potency or ED problem and create a treatment plan which is optimized for your problem. All guideline methods, medications, nutrition and life style recommendations will be included in your treatment plan – together with the most state of the art and safe stem cell based therapies.

What are Stem Cells, why does a Stem Cell therapy for ED work and what is revolutionary about the Anova IRM approach to treat ED and Impotence?

Stem Cells are cells that possess the ability to divide into many subgroups of cells, and are responsible for many controlling functions in the body through their paracrine communication (growth factors, hormones, cytokines, antiinflammatory factors, extracellular vesicles, exosomes and microRNA). We have a full length article describing some of the medically relevant properties of stem cells and stem cell derived treatments here. Over 20 pre-clinical studies have been published so far, on different stem cell models and different damage models in animals since 2004. In 2016 two Phase I study results were published for Bone Marrow Concentrate (BMC) and fat derived Mesenchymal Stem Cells (adMSCs). Both, the human and animal studies universally showed an improvement with different interpretations of the results. A breakthough study was published by Albersen et al. in 2010 that showed that the effects of stem cell injections cannot be accounted to direct differentiation and adherence of the injected stem cells, but rather from their paracrine substances. Almost none of the injected (and specifically marked) cells were found after autopsy, despite the improvement of the condition of the animal. The Anova Stem Cell Secretome therapy as the next generation of stem cell-based therapies is designed and optimized for producing high concentration of these paracrine substances under laboratory designed conditions with superior quality. This insight is a quantum leap for the treatment of erectile dysfunction and impotence with stem cells. We are the first to take full advantage of the stem cells and harness their regenerative powers. With the Anova Secretome therapy we were able to provide a highly effective, safe and legal way to use stem cells as a “factory” to produce the paracrine factors in incredibly high concentrations under GMP Laboratory conditions. Combined with cell and tissue growth factors from PRP (Platelet Rich Plasma) and BMC (Bone Marrow Concentrate) caring a variety of pluripotent stromal cells, we are able to provide natural, personally tailored, regenerative therapies for the different underlying pathologies of Erectile Dysfunction and Impotence.


 
References and Literature - Stem Cell-based Therapies and Erectile Dysfunction (Click for more)

i

    Shan, H., Chen, F., Zhang, T., He, S., Xu, L., & Wei, A. (2015). Stem cell therapy for erectile dysfunction of cavernous nerve injury rats: A systematic review and meta-analysis. PLoS ONE, 10(4), 1–23. http://doi.org/10.1371/journal.pone.0121428

ii

    You, Dalsan, et al. "Comparative Study of Autologous Stromal Vascular Fraction and Adipose‐Derived Stem Cells for Erectile Function Recovery in a Rat Model of Cavernous Nerve Injury." Stem cells translational medicine 4.4 (2015): 351-358.

iii

    Chen, X., Yang, Q., Zheng, T., Bian, J., Sun, X., Shi, Y., … Deng, C. (2016). Neurotrophic Effect of Adipose Tissue-Derived Stem Cells on Erectile Function Recovery by Pigment Epithelium-Derived Factor Secretion in a Rat Model of Cavernous Nerve Injury, 2016.

iv

    Yiou, R., Hamidou, L., Birebent, B., Bitari, D., Lecorvoisier, P., Contremoulins, I., … Rouard, H. (2016). Safety of Intracavernous Bone Marrow-Mononuclear Cells for Postradical Prostatectomy Erectile Dysfunction: An Open Dose-Escalation Pilot Study. European Urology, 69(6), 988–991. http://doi.org/10.1016/j.eururo.2015.09.026

v

    Wang, X. Y., Liu, C. L., Li, S. D., Xu, Y., Chen, P., Liu, Y., … Yang, M. H. (2015). Hypoxia precondition promotes adipose-derived mesenchymal stem cells based repair of diabetic erectile dysfunction via augmenting angiogenesis and neuroprotection. PLoS ONE, 10(3), 1–18. http://doi.org/10.1371/journal.pone.0118951

vi

    Haahr, M. K., Jensen, C. H., Toyserkani, N. M., Andersen, D. C., Damkier, P., S??rensen, J. A., … Sheikh, S. P. (2016). Safety and Potential Effect of a Single Intracavernous Injection of Autologous Adipose-Derived Regenerative Cells in Patients with Erectile Dysfunction Following Radical Prostatectomy: An Open-Label Phase I Clinical Trial. EBioMedicine, 5, 204–210. http://doi.org/10.1016/j.ebiom.2016.01.024

vii

  • Bochinski D, Lin GT, Nunes L, Carrion R, Rahman N, Lin CS, et al. (2004) The effect of neural embryonic stem cell therapy in a rat model of cavernosal nerve injury. Bju Int 94: 904–09. PMID: 15476533
  • Kim Y, de Miguel F, Usiene I, Rahman N, Yoshimura N, Huard J, et al. (2006) Injection of skeletal muscle-derived cells into the penis improves erectile function. Int J Impot Res 18: 329–34. PMID: 16341028
  • Fall PA, Izikki M, Tu L, Swieb S, Giuliano F, Bernabe J, et al. (2009) Apoptosis and effects of intracavernous bone marrow cell injection in a rat model of postprostatectomy erectile dysfunction. Eur Urol. 2009; 56: 716–25. doi: 10.1016/j.eururo.2008.09.059 PMID: 18922625
  • Albersen M, Fandel TM, Lin G, Wang G, Banie L, Lin CS, et al. (2010) Injections of adipose tissue-derived stem cells and stem cell lysate improve recovery of erectile function in a rat model of cavernous nerve injury. J Sex Med 7: 3331–40. doi: 10.1111/j.1743-6109.2010.01875.x PMID: 20561166
  • Kendirci M, Trost L, Bakondi B, Whitney MJ, Hellstrom WJ, Spees JL (2010) Transplantation of nonhematopoietic adult bone marrow stem/progenitor cells isolated by p75 nerve growth factor receptor into the penis rescues erectile function in a rat model of cavernous nerve injury. J Urol 184: 1560–66. doi: 10.1016/j.juro.2010.05.088 PMID: 20728109
  • Lin G, Qiu X, Fandel T, Banie L, Wang G, Lue TF, et al. (2011) Tracking intracavernously injected adipose-derived stem cells to bone marrow. Int J Impot Res 23: 268–75. doi: 10.1038/ijir.2011.38 PMID: 21796145
  • Lin G, Albersen M, Harraz AM, Fandel TM, Garcia M, McGrath MH, et al. (2011) Cavernous nerve repair with allogenic adipose matrix and autologous adipose-derived stem cells. Urology 77: 1501–09. Woo JC, Bae WJ, Kim SJ, Kim SD, Sohn DW, Hong SH, et al. (2011) Transplantation of muscle-derived stem cells into the corpus cavernosum restores erectile function in a rat model of cavernous nerve injury.
  • Korean J Urol 52: 359–63. doi: 10.4111/kju.2011.52.5.359 PMID: 21687398 Fandel TM, Albersen M, Lin G, Qiu X, Ning H, Banie L, et al. (2012) Recruitment of intracavernously injected adipose-derived stem cells to the major pelvic ganglion improves erectile function in a rat model of cavernous nerve injury. Eur Urol 61: 201–10. doi: 10.1016/j.eururo.2011.07.061 PMID: 21824718
  • Kim SJ, Park SH, Sung YC, Kim SW (2012) Effect of mesenchymal stem associated to matrixen on the erectile function in the rat model with bilateral cavernous nerve crushing injury. Int Braz J Urol 38: 833– 41. PMID: 23302404
  • Kim SJ, Choi SW, Hur KJ, Park SH, Sung YC, Ha YS, et al. (2012) Synergistic effect of mesenchymal stem cells infected with recombinant adenovirus expressing human BDNF on erectile function in a rat model of cavernous nerve injury. Korean J Urol 53: 726–32. doi: 10.4111/kju.2012.53.10.726 PMID: 23136635
  • Kovanecz I, Rivera S, Nolazco G, Vernet D, Segura D, Gharib S, et al. (2012) Separate or combined treatments with daily sildenafil, molsidomine, or muscle-derived stem cells prevent erectile dysfunction in a rat model of cavernosal nerve damage. J Sex Med 9: 2814–26. doi: 10.1111/j.1743-6109.2012. 02913.x PMID: 22974131
  • Piao S, Kim IG, Lee JY, Hong SH, Kim SW, Hwang TK, et al. (2012) Therapeutic effect of adipose-derived stem cells and BDNF-immobilized PLGA membrane in a rat model of cavernous nerve injury. J Sex Med 9: 1968–79. doi: 10.1111/j.1743-6109.2012.02760.x PMID: 22642440
  • Qiu X, Villalta J, Ferretti L, Fandel TM, Albersen M, Lin G, et al. (2012) Effects of intravenous injection of adipose-derived stem cells in a rat model of radiation therapy-induced erectile dysfunction. J Sex Med 9: 1834–41. doi: 10.1111/j.1743-6109.2012.02753.x PMID: 22548750

viii

    Albersen M, Fandel TM, Lin G, Wang G, Banie L, Lin CS, et al. (2010) Injections of adipose tissue-derived stem cells and stem cell lysate improve recovery of erectile function in a rat model of cavernous nerve injury. J Sex Med 7: 3331–40. doi: 10.1111/j.1743-6109.2010.01875.x PMID: 20561166

viiii

    Tewari, A., et al. "Technique of traction-free nerve-sparing robotic prostatectomy: delicate tissue handling by real-time penile oxygen monitoring." International journal of impotence research 24.1 (2012): 11.

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