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1. He Y, He W, Qin G, Luo J, Xiao M. Transplantation KCNMA1 modified bone marrow-mesenchymal stem cell therapy for diabetes mellitus-induced erectile dysfunction. Andrologia. 2014;46(5):479-486. doi:10.1111/and.12104.
2. Mathiasen AB, Qayyum AA, Jørgensen E, et al. Bone marrow-derived mesenchymal stromal cell treatment in patients with severe ischaemic heart failure: a randomized placebo-controlled trial ({MSC}-{HF} trial). Eur Heart J. 2015;36(27):1744-1753. doi:10.1093/eurheartj/ehv136.
3. Mathiasen AB, Qayyum AA, Jørgensen E, et al. Interventional cardiology Bone marrow-derived mesenchymal stromal cell treatment in patients with severe ischaemic heart failure : a randomized placebo-controlled trial. 2015. doi:10.1093/eurheartj/ehv136.
4. Liao H-T, Chen C-T. Osteogenic potential: Comparison between bone marrow and adipose-derived mesenchymal stem cells. World J Stem Cells. 2014;6(3):288-295. doi:10.4252/wjsc.v6.i3.288.
5. Terai S, Ishikawa T, Omori K, et al. Improved liver function in patients with liver cirrhosis after autologous bone marrow cell infusion therapy. Stem Cells. 2006;24(10):2292-2298. doi:10.1634/stemcells.2005-0542.
6. 2015_Cao_Spine-Journal_Bone-marrow-mesenchymal-stem-cells-slow-intervertebral-disc-degeneration-through-the-NF-κB-pathway.pdf.
7. Zhao J, Zhang Q, Wang Y, Li Y. Uterine Infusion With Bone Marrow Mesenchymal Stem Cells Improves Endometrium Thickness in a Rat Model of Thin Endometrium. Reprod Sci. 2015;22(2):181-188. doi:10.1177/1933719114537715.
8. Fekete N, Rojewski MT, Fürst D, et al. GMP-compliant isolation and large-scale expansion of bone marrow-derived MSC. PLoS One. 2012;7(8). doi:10.1371/journal.pone.0043255.
9. Elman JS, Li M, Wang F, Gimble JM, Parekkadan B. A comparison of adipose and bone marrow-derived mesenchymal stromal cell secreted factors in the treatment of systemic inflammation. 2014:4-11.
10. Li C, Wu X, Tong J, et al. Comparative analysis of human mesenchymal stem cells from bone marrow and adipose tissue under xeno-free conditions for cell therapy. Stem Cell Res Ther. 2015;6(1):55. doi:10.1186/s13287-015-0066-5.
11. Books J, Sign R. Safety of Intracavernous Bone Marrow-Mononuclear Cells for Postrad ... Safety of Intracavernous Bone Marrow-Mononuclear Cells for Postradical Prostatectomy Erectile Dysfunction : An Open Dose-Escalation Pilot Study Safety of Intracavernous Bone Marrow-Mon. 2017:2015-2017.
12. Rinker TE, Hammoudi TM, Kemp ML, Lu H, Temenoff JS. Interactions between mesenchymal stem cells, adipocytes, and osteoblasts in a 3D tri-culture model of hyperglycemic conditions in the bone marrow microenvironment. Integr Biol (Camb). 2014;6(3):324-337. doi:10.1039/c3ib40194d.
13. Al-sayegh H, Bashir J, Goodyear S, Freeman MD. A prospective multi-site registry study of a specific protocol of autologous bone marrow concentrate for the treatment of shoulder rotator cuff tears and osteoarthritis. 2015:269-276.
14. Rager TM, Olson JK, Zhou Y, Wang Y, Besner GE. Exosomes secreted from bone marrow-derived mesenchymal stem cells protect the intestines from experimental necrotizing enterocolitis. J Pediatr Surg. 2016;51(6):942-947. doi:10.1016/j.jpedsurg.2016.02.061.
15. Tate-oliver K, Alexander RW. Density Platelet-Rich Plasma or Bone Marrow.
16. Tang K, Yan J, Shen Y, et al. Tracing type 1 diabetic Tibet miniature pig ’ s bone marrow mesenchymal stem cells in vitro by magnetic resonance imaging. 2014;6:123-131. doi:10.1111/1753-0407.12084.
17. Wang X, Mamillapalli R, Mutlu L, Du H, Taylor HS. Chemoattraction of bone marrow-derived stem cells towards human endometrial stromal cells is mediated by estradiol regulated CXCL12 and CXCR4 expression. Stem Cell Res. 2015;15(1):14-22. doi:10.1016/j.scr.2015.04.004.
18. Rambaldi A, Capelli C, Domenghini M, et al. Human platelet lysate allows expansion and clinical grade production of mesenchymal stromal cells from small samples of bone marrow aspirates or marrow filter washouts. 2007:785-791. doi:10.1038/sj.bmt.1705798.
19. Mushtaq M, Williams AR, Suncion VY, et al. Transendocardial Mesenchymal Stem Cells and Mononuclear Bone Marrow Cells for Ischemic Cardiomyopathy The TAC-HFT Randomized Trial. 2015;16960. doi:10.1001/jama.2013.282909.
20. 2014 Autografting of bone marrow mesenchymal stem cells alleviates streptozotocin induced diabetes in miniature pigs.pdf.
21. Program T, Marga- P, Kingdom U. Bone Marrow Therapies for Chronic Heart Dis- ease. 2015:1-12. doi:10.1002/stem.2080.
22. Biology C, Cell R, Eye N, Institutes N, Infor- AS. Bone Marrow-Derived Mesenchymal Stem Cells-Derived Exosomes Promote Survival of Retinal Ganglion Cells Through miRNA-Dependent Mechanisms. 2017:1273-1285. doi:10.1002/sctm.12056.
23. Jeong Y, Kyu H, Hwa H, Chan Y. Cellular Physiology and Biochemistr y Biochemistry Direct Comparison of Human Mesenchymal Stem Cells Derived from Adipose Tissues and Bone Marrow in Mediating Neovascularization in Response to Vascular Ischemia. Cell Physiol Biochem. 2007;20:867-876.
24. Shutian S, Shaoping N, Xingxin W, et al. GW25-e3198 The combination of transforming growth factor β1 and 5-azacytidine improve the differentiation effects of rat Bone marrow mesenchymal stem cells into cardiomyocytes. J Am Coll Cardiol. 2014;64(16):C21. doi:10.1016/j.jacc.2014.06.105.
25. Narita T, Suzuki K. Bone marrow-derived mesenchymal stem cells for the treatment of heart failure. Heart Fail Rev. 2014:53-68. doi:10.1007/s10741-014-9435-x.
26. Elman JS, Li M, Wang F, Gimble JM, Parekkadan B. A comparison of adipose and bone marrow-derived mesenchymal stromal cell secreted factors in the treatment of systemic inflammation. J Inflamm (Lond). 2014;11:1. doi:10.1186/1476-9255-11-1.
27. Dong X, Zhu F, Liu Q, et al. Transplanted bone marrow mesenchymal stem cells protects myocardium by regulating 14-3-3 protein in a rat model of diabetic cardiomyopathy. 2014;7(7):3714-3723.
28. Huang L, Wu W, Luo F. Umbilical Cord Mesenchymal Stromal Cell With Autologous Bone Marrow Cell Transplantation in Established Type 1 Diabetes : A Pilot Randomized Controlled Open-Label Clinical Study to Assess Safety and Impact on Insulin Secretion. 2016:1-9. doi:10.2337/dc15-0171.
29. Sanghi V, Sethi D, Harris KL, et al. International Journal of the Cardiovascular Academy Autologous bone marrow concentrate enriched in progenitor cells — An adjuvant in the treatment of acute myocardial infarction. IJCAC. 2016. doi:10.1016/j.ijcac.2016.04.001.
30. Leyh M, Seitz A, Dürselen L, et al. Subchondral bone influences chondrogenic differentiation and collagen production of human bone marrow-derived mesenchymal stem cells and articular chondrocytes. 2014:1-18. doi:10.1186/s13075-014-0453-9.
31. Surgery M, Stomatological S, Material CP, et al. T ISSUE -S PECIFIC S TEM C ELLS Adiponectin Regulates Bone Marrow Mesenchymal Stem Cell Niche Through a Unique Signal Transduction Pathway : An Approach for Treating Bone Disease in Diabetes. 2015:240-252.
32. Li C, Wu X, Tong J, et al. Comparative analysis of human mesenchymal stem cells from bone marrow and adipose tissue under xeno-free conditions for cell therapy. Stem Cell Res Ther. 2015;6(1):55. doi:10.1186/s13287-015-0066-5.
33. Mead B, Logan A, Berry M, Leadbeater W, Scheven BA. Paracrine-Mediated Neuroprotection and Neuritogenesis of Axotomised Retinal Ganglion Cells by Human Dental Pulp Stem Cells: Comparison with Human Bone Marrow and Adipose-Derived Mesenchymal Stem Cells. PLoS One. 2014;9(10):e109305. doi:10.1371/journal.pone.0109305.
34. Cao C, Zou J, Liu X, Shapiro A. Bone marrow mesenchymal stem cells slow intervertebral disc degeneration through the NF- k B pathway. Spine J. 2015;15(3):530-538. doi:10.1016/j.spinee.2014.11.021.
35. Li C, Wu X, Tong J, et al. Comparative analysis of human mesenchymal stem cells from bone marrow and adipose tissue under xeno-free conditions for cell therapy. ??? 2015. doi:10.1186/s13287-015-0066-5.
36. Narita T, Suzuki K. Bone marrow-derived mesenchymal stem cells for the treatment of heart failure. 2015:53-68. doi:10.1007/s10741-014-9435-x.
37. Heldman AW, DiFede DL, Fishman JE, et al. Transendocardial Mesenchymal Stem Cells and Mononuclear Bone Marrow Cells for Ischemic Cardiomyopathy. Jama. 2014;311(1):62. doi:10.1001/jama.2013.282909.
38. Baglio SR, Rooijers K, Koppers-Lalic D, et al. Human bone marrow- and adipose-mesenchymal stem cells secrete exosomes enriched in distinctive miRNA and tRNA species. Stem Cell Res Ther. 2015;6(1):127. doi:10.1186/s13287-015-0116-z.
39. Islam MN, Das SR, Emin MT, et al. Mitochondrial transfer from bone-marrow-derived stromal cells to pulmonary alveoli protects against acute lung injury. Nat Med. 2012;18(5):759-765. doi:10.1038/nm.2736.
40. Baglio SR, Rooijers K, Koppers-Lalic D, et al. Human bone marrow- and adipose-mesenchymal stem cells secrete exosomes enriched in distinctive miRNA and tRNA species. Stem Cell Res Ther. 2015;6(1):127. doi:10.1186/s13287-015-0116-z.
41. Bian S, Zhang L, Duan L, et al. Extracellular vesicles derived from human bone marrow mesenchymal stem cells promote angiogenesis in a rat myocardial infarction model. J Mol Med (Berl). 2014;92(4):387-397. doi:10.1007/s00109-013-1110-5.
42. Shabbir A, Zisa D, Suzuki G, Lee T. Heart failure therapy mediated by the trophic activities of bone marrow mesenchymal stem cells: a noninvasive therapeutic regimen. Am J Physiol Heart Circ Physiol. 2009;296(6):H1888-H1897. doi:10.1152/ajpheart.00186.2009.
43. Czubak PB, Bojarska-junak A, Tabarkiewicz J, Putowski LB. A Modified Method of Insulin Producing Cells ’ Generation from Bone Marrow-Derived Mesenchymal Stem Cells. 2014;2014:1-7. doi:10.1155/2014/628591.
44. Baglio SR, Rooijers K, Koppers-Lalic D, et al. Human bone marrow- and adipose-mesenchymal stem cells secrete exosomes enriched in distinctive miRNA and tRNA species. Stem Cell Res Ther. 2015;6(1):127. doi:10.1186/s13287-015-0116-z.
45. am Esch JS, Knoefel WT, Klein M, et al. Portal application of autologous CD133+ bone marrow cells to the liver: a novel concept to support hepatic regeneration. Stem Cells. 2005;23(4):463-470. doi:10.1634/stemcells.2004-0283.
46. Wang X, Nie S-P, Zhen L, et al. TCTAP A-156 Retrograde Coronary Vein Delivery of Basic Fibroblast Growth Enhances Bone Marrow Mesenchymal Stem Cells Engraftment for Myocardial Repair in a Canine Infarct Model. J Am Coll Cardiol. 2014;63(12):S44. doi:10.1016/j.jacc.2014.02.189.
47. Al-sayegh H, Bashir J, Goodyear S, Freeman MD. A prospective multi-site registry study of a specific protocol of autologous bone marrow concentrate for the treatment of shoulder rotator cuff tears and osteoarthritis. 2015:269-276.
48. Gabr MM, Zakaria MM, Refaie AF, et al. Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells into Insulin-Producing Cells : Evidence for Further Maturation In Vivo. 2015;2015.
49. Pai M, Zacharoulis D, Milicevic MN, et al. Autologous infusion of expanded mobilized adult bone marrow-derived CD34+ cells into patients with alcoholic liver cirrhosis. Am J Gastroenterol. 2008;103(8):1952-1958. doi:10.1111/j.1572-0241.2008.01993.x.
50. Kushida T, Iida H. Bone marrow cell transplantation efficiently repairs tendon and ligament injuries. Front Cell Dev Biol. 2014;2(July):1-4. doi:10.3389/fcell.2014.00027.
51. Schulte J, Knoefel T, Klein M, et al. Portal Application of Autologous CD133 + Bone Marrow Cells to the. 2005:463-470. doi:10.1634/stemcells.2004-0283.
52. Scott M, Ph D, Marley SB, et al. Autologous Infusion of Expanded Mobilized Adult Bone Marrow-Derived CD34 + Cells Into Patients With Alcoholic Liver Cirrhosis. 2008:1952-1958. doi:10.1111/j.1572-0241.2008.01993.x.
53. 2015 Murine Sca1+Lin− bone marrow contains an endodermal precursor population that differentiates into hepatocytes.pdf.
54. Prabhakar S, Marwaha N, Lal V, Sharma RR, Rajan R, Khandelwal N. Autologous bone marrow-derived stem cells in amyotrophic lateral sclerosis: A pilot study. Neurol India. 2012;60(5):465-469. doi:10.4103/0028-3886.103185.
55. Naaldijk Y, Jäger C, Fabian C, et al. Effect of systemic transplantation of bone marrow-derived mesenchymal stem cells on neuropathology markers in APP/PS1 Alzheimer mice. Neuropathol Appl Neurobiol. 2016:1-16. doi:10.1111/nan.12319.
56. Nicola M Di, Carlo-stella C, Magni M, et al. induced by cellular or nonspecific mitogenic stimuli Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. 2013;99(10):3838-3843. doi:10.1182/blood.V99.10.3838.
57. Tzameret A, Sher I, Belkin M, et al. Epiretinal transplantation of human bone marrow mesenchymal stem cells rescues retinal and vision function in a rat model of retinal degeneration. Stem Cell Res. 2015;15(2):387-394. doi:10.1016/j.scr.2015.08.007.
58. Augello A, Tasso R, Negrini SM, Cancedda R, Pennesi G. Cell therapy using allogeneic bone marrow mesenchymal stem cells prevents tissue damage in collagen-induced arthritis. Arthritis Rheum. 2007;56(4):1175-1186. doi:10.1002/art.22511.
59. Capelli C, Domenghini M, Borleri G, et al. Human platelet lysate allows expansion and clinical grade production of mesenchymal stromal cells from small samples of bone marrow aspirates or marrow filter washouts. Bone Marrow Transplant. 2007;40(8):785-791. doi:10.1038/sj.bmt.1705798.
60. Sanghi V, Sethi D, Harris KL, et al. International Journal of the Cardiovascular Academy Autologous bone marrow concentrate enriched in progenitor cells — An adjuvant in the treatment of acute myocardial infarction. IJCAC. 2016. doi:10.1016/j.ijcac.2016.04.001.
61. Oe K, Kushida T, Okamoto N, et al. New strategies for anterior cruciate ligament partial rupture using bone marrow transplantation in rats. Stem Cells Dev. 2011;20(4):671-679. doi:10.1089/scd.2010.0182.
62. Ahmed HH, Salem AM, Atta HM, et al. Updates in the pathophysiological mechanisms of Parkinson’s disease: Emerging role of bone marrow mesenchymal stem cells. World J Stem Cells. 2016;8(3):106. doi:10.4252/wjsc.v8.i3.106.
63. Cai J, Wu Z, Xu X, et al. Umbilical Cord Mesenchymal Stromal Cell With Autologous Bone Marrow Cell Transplantation in Established Type 1 Diabetes: A Pilot Randomized Controlled Open-Label Clinical Study to Assess Safety and Impact on Insulin Secretion. Diabetes Care. 2015:dc150171. doi:10.2337/dc15-0171.
64. Abdel Aziz MT, Wassef MAA, Ahmed HH, et al. The role of bone marrow derived-mesenchymal stem cells in attenuation of kidney function in rats with diabetic nephropathy. Diabetol Metab Syndr. 2014;6(1):34. doi:10.1186/1758-5996-6-34.
65. Al-sayegh H, Bashir J, Goodyear S, Freeman MD. A prospective multi-site registry study of a specific protocol of autologous bone marrow concentrate for the treatment of shoulder rotator cuff tears and osteoarthritis. 2015:269-276.
66. Shabbir A, Zisa D, Suzuki G, Lee T. Heart failure therapy mediated by the trophic activities of bone marrow mesenchymal stem cells: a noninvasive therapeutic regimen. Am J Physiol Heart Circ Physiol. 2009;296(6):H1888-H1897. doi:10.1152/ajpheart.00186.2009.
67. Collino F, Deregibus MC, Bruno S, et al. Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs. PLoS One. 2010;5(7). doi:10.1371/journal.pone.0011803.
68. Sanghi V, Sethi D, Harris KL, et al. International Journal of the Cardiovascular Academy Autologous bone marrow concentrate enriched in progenitor cells — An adjuvant in the treatment of acute myocardial infarction. IJCAC. 2016. doi:10.1016/j.ijcac.2016.04.001.
69. Fekete N, Rojewski MT, Fürst D, et al. GMP-compliant isolation and large-scale expansion of bone marrow-derived MSC. PLoS One. 2012;7(8). doi:10.1371/journal.pone.0043255.
70. C. L, S.A. M, M. A, S.H. V, A. F-G. Exosomes mediate the cytoprotective effects of bone Marrow-Derived Stromal Cells (MSCS) on the hypoxic lung. Am J Respir Crit Care Med. 2011;183(1 MeetingAbstracts):no pagination. http://ajrccm.atsjournals.org/cgi/reprint/183/1_MeetingAbstracts/A3764?sid=f0b58cd0-9f08-401b-bb88-e9a3268d044f%5Cnhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=emed10&NEWS=N&AN=70848115.
71. Islam MN, Das SR, Emin MT, et al. Mitochondrial transfer from bone-marrow-derived stromal cells to pulmonary alveoli protects against acute lung injury. Nat Med. 2012;18(5):759-765. doi:10.1038/nm.2736.
72. Yoon SH, Shim YS, Park YH, et al. Complete spinal cord injury treatment using autologous bone marrow cell transplantation and bone marrow stimulation with granulocyte macrophage-colony stimulating factor: Phase I/II clinical trial. Stem Cells. 2007;25(8):2066-2073. doi:10.1634/stemcells.2006-0807.
73. Hernigou P, Guissou I, Homma Y, et al. Percutaneous injection of bone marrow mesenchymal stem cells for ankle non-unions decreases complications in patients with diabetes. Int Orthop. 2015. doi:10.1007/s00264-015-2738-2.
74. Davies OG, Smith AJ, Cooper PR, Shelton RM, Scheven BA. Cryobiology The effects of cryopreservation on cells isolated from adipose , bone marrow and dental pulp tissues q. Cryobiology. 2014;69(2):342-347. doi:10.1016/j.cryobiol.2014.08.003.
75. C. L, S.A. M, M. A, S.H. V, A. F-G. Exosomes mediate the cytoprotective effects of bone Marrow-Derived Stromal Cells (MSCS) on the hypoxic lung. Am J Respir Crit Care Med. 2011;183(1 MeetingAbstracts):no pagination. http://ajrccm.atsjournals.org/cgi/reprint/183/1_MeetingAbstracts/A3764?sid=f0b58cd0-9f08-401b-bb88-e9a3268d044f%5Cnhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=emed10&NEWS=N&AN=70848115.
76. Tang KX, Shen YF, Li BY, et al. Tracing type 1 diabetic Tibet miniature pig’s bone marrow mesenchymal stem cells in vitro by magnetic resonance imaging. J Diabetes. 2013;6:123-131. doi:10.1111/1753-0407.12084.
77. Associates RM, Biosciences C. T RANSLATIONAL AND C LINICAL Percutaneous Injection of Autologous Bone Marrow Concentrate Cells Significantly Reduces Lumbar Discogenic Pain Through 12 Months. 2015:146-156.
78. Kasahara Y, Matsuyama T, Taguchi A. Treatment of Autologous Bone Marrow Mononuclear Cells for Acute and Subacute Stroke Cell Therapy for Acute / Subacute Stroke. 2015:37-46. doi:10.1007/978.
79. Qi X, Zhang J, Yuan H, et al. Exosomes secreted by human-induced pluripotent stem cell-derived mesenchymal stem cells repair critical-sized bone defects through enhanced angiogenesis and osteogenesis in osteoporotic rats. Int J Biol Sci. 2016;12(7):836-849. doi:10.7150/ijbs.14809.
80. Shabbir A, Zisa D, Suzuki G, Lee T. Heart failure therapy mediated by the trophic activities of bone marrow mesenchymal stem cells: a noninvasive therapeutic regimen. Am J Physiol Heart Circ Physiol. 2009;296(6):H1888-H1897. doi:10.1152/ajpheart.00186.2009.
81. Nicola M Di, Carlo-stella C, Magni M, et al. induced by cellular or nonspecific mitogenic stimuli Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. 2013;99(10):3838-3843. doi:10.1182/blood.V99.10.3838.
82. Capelli C, Domenghini M, Borleri G, et al. Human platelet lysate allows expansion and clinical grade production of mesenchymal stromal cells from small samples of bone marrow aspirates or marrow filter washouts. Bone Marrow Transplant. 2007;40(8):785-791. doi:10.1038/sj.bmt.1705798.
83. Yiou R, Hamidou L, Birebent B, et al. Safety of Intracavernous Bone Marrow-Mononuclear Cells for Postradical Prostatectomy Erectile Dysfunction: An Open Dose-Escalation Pilot Study. Eur Urol. 2016;69(6):988-991. doi:10.1016/j.eururo.2015.09.026.
84. Neural I, Medicine R, Science M. Complete Spinal Cord Injury Treatment Using Autologous Bone Marrow Cell Transplantation and Bone Marrow Stimulation with Granulocyte Macrophage-Colony Stimulating Factor : Phase I / II Clinical Trial. 2007:2066-2073. doi:10.1634/stemcells.2006-0807.
85. Collino F, Deregibus MC, Bruno S, et al. Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs. PLoS One. 2010;5(7). doi:10.1371/journal.pone.0011803.
86. Yu L, Tu Q, Han Q, et al. Adiponectin Regulates Bone Marrow Mesenchymal Stem Cell Niche Through a Unique Signal Transduction Pathway : An Approach for Treating Bone Disease in Diabetes. Stem Cells. 2015;33:240-252. doi:10.1002/stem.1844.
87. Lyra AC, Soares MB, da Silva LF, et al. Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease. World J Gastroenterol. 2007;13(7):1067-1073. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17373741.
88. Song F, Tang J, Geng R, et al. Comparison of the efficacy of bone marrow mononuclear cells and bone mesenchymal stem cells in the treatment of osteoarthritis in a sheep model. 2014;7(4):1415-1426.
89. Nakamura-ishizu A, Takubo K, Kobayashi H, Suzuki-inoue K. CLEC-2 in megakaryocytes is critical for maintenance of hematopoietic stem cells in the bone marrow. 2015. doi:10.1084/jem.20150057.
90. Leyh M, Seitz A, Dürselen L, et al. Subchondral bone influences chondrogenic differentiation and collagen production of human bone marrow-derived mesenchymal stem cells and articular chondrocytes. 2014:1-18. doi:10.1186/s13075-014-0453-9.
91. Beane OS, Fonseca VC, Cooper LL, Koren G. Impact of Aging on the Regenerative Properties of Bone Marrow- , Muscle- , and Adipose-Derived Mesenchymal Stem / Stromal Cells. 2014:1-22. doi:10.1371/journal.pone.0115963.
92. Nicola M Di, Carlo-stella C, Magni M, et al. induced by cellular or nonspecific mitogenic stimuli Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. 2013;99(10):3838-3843. doi:10.1182/blood.V99.10.3838.
93. Ribeiro A, Laranjeira P, Mendes S, et al. Mesenchymal stem cells from umbilical cord matrix, adipose tissue and bone marrow exhibit different capability to suppress peripheral blood B, natural killer and T cells. Stem Cell Res Ther. 2013;4(5):125. doi:10.1186/scrt336.
94. Observer C, Alto P, Program T, Hospital M. T RANSLATIONAL AND C LINICAL Bone Marrow Therapies for Chronic Heart Disease. 2015:3212-3227. doi:10.1002/stem.2080.
95. Beane OS, Fonseca VC, Cooper LL, Koren G. Impact of Aging on the Regenerative Properties of Bone Marrow- , Muscle- , and Adipose-Derived Mesenchymal Stem / Stromal Cells. 2014:1-22. doi:10.1371/journal.pone.0115963.
96. Rodriguez-Menocal L, Shareef S, Salgado M, Shabbir A, Van Badiavas E. Role of whole bone marrow, whole bone marrow cultured cells, and mesenchymal stem cells in chronic wound healing. Stem Cell Res Ther. 2015;6(1):1-11. doi:10.1186/s13287-015-0001-9.
97. Islam MN, Das SR, Emin MT, et al. Mitochondrial transfer from bone-marrow-derived stromal cells to pulmonary alveoli protects against acute lung injury. Nat Med. 2012;18(5):759-765. doi:10.1038/nm.2736.
98. Venkataramana NK, Kumar SK V, Balaraju S, et al. Open-labeled study of unilateral autologous bone-marrow-derived mesenchymal stem cell transplantation in Parkinson’s disease. Transl Res. 2010;155(2):62-70. doi:10.1016/j.trsl.2009.07.006.
99. Czubak P, Bojarska-Junak A, Tabarkiewicz J, Putowski L. A modified method of insulin producing cells’ generation from bone marrow-derived mesenchymal stem cells. J Diabetes Res. 2014;2014:628591. doi:10.1155/2014/628591.
100. Shutian S, Shaoping N, Xingxin W, et al. GW25-e3198 The combination of transforming growth factor β1 and 5-azacytidine improve the differentiation effects of rat Bone marrow mesenchymal stem cells into cardiomyocytes. J Am Coll Cardiol. 2014;64(16):C21. doi:10.1016/j.jacc.2014.06.105.
101. Yang J, Kaur K, Ong LL, Eisenberg CA, Eisenberg LM. Inhibition of G9a Histone Methyltransferase Converts Bone Marrow Mesenchymal Stem Cells to Cardiac Competent Progenitors. Stem Cells Int. 2015;2015:1-12. doi:10.1155/2015/270428.
102. Biology C, Cell R, Eye N, Institutes N, Infor- AS. Bone Marrow-Derived Mesenchymal Stem Cells-Derived Exosomes Promote Survival of Retinal Ganglion Cells Through miRNA-Dependent Mechanisms. 2017. doi:10.1002/sctm.12056.
103. Chen J, Venkat P, Chopp M. Bone Marrow Mesenchymal Stromal Cell Transplantation : A Neurorestorative Therapy for Stroke. 2015:47-69. doi:10.1007/978.
104. Kondo M, Kamiya H, Himeno T, et al. Therapeutic efficacy of bone marrow-derived mononuclear cells in diabetic polyneuropathy is impaired with aging or diabetes. J Diabetes Investig. 2015;6(2):140-149. doi:10.1111/jdi.12272.
105. Nakamura-ishizu A, Takubo K, Kobayashi H, Suzuki-inoue K. CLEC-2 in megakaryocytes is critical for maintenance of hematopoietic stem cells in the bone marrow. 2015. doi:10.1084/jem.20150057.
106. Gabr MM, Zakaria MM, Refaie AF, et al. Generation of insulin-producing cells from human bone marrow-derived mesenchymal stem cells: comparison of three differentiation protocols. Biomed Res Int. 2014;2014:832736. doi:10.1155/2014/832736.
107. Tzameret A, Sher I, Belkin M, et al. Epiretinal transplantation of human bone marrow mesenchymal stem cells rescues retinal and vision function in a rat model of retinal degeneration ☆. Stem Cell Res. 2015;15(2):387-394. doi:10.1016/j.scr.2015.08.007.
108. C. L, S.A. M, M. A, S.H. V, A. F-G. Exosomes mediate the cytoprotective effects of bone Marrow-Derived Stromal Cells (MSCS) on the hypoxic lung. Am J Respir Crit Care Med. 2011;183(1 MeetingAbstracts):no pagination. http://ajrccm.atsjournals.org/cgi/reprint/183/1_MeetingAbstracts/A3764?sid=f0b58cd0-9f08-401b-bb88-e9a3268d044f%5Cnhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=emed10&NEWS=N&AN=70848115.
109. Sun J, Wei ZZ, Gu X, et al. Intranasal delivery of hypoxia-preconditioned bone marrow-derived mesenchymal stem cells enhanced regenerative effects after intracerebral hemorrhagic stroke in mice. Exp Neurol. 2015. doi:10.1016/j.expneurol.2015.03.011.
110. Talaat M, Aziz A, Abdel M, et al. The role of bone marrow derived-mesenchymal stem cells in attenuation of kidney function in rats with diabetic nephropathy. 2014:1-10.
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Patient Services at Anova IRM Stem Cell Center

Located in the Center of Germany

Less than 20 minutes from Frankfurt Airport

Personalized Therapies for Your Improvement with State-of-the-art Stem Cell products and latest Regenerative Medical Programs

100% Guarantee on Cutting-edge, safe and high quality stem cell products with 20-times increased cell counts

Highest Precision with Latest Radiological Imaging Modalities for Superior Image Guided Procedures

Diagnostic Work-ups with World-Class MRI scans, Advanced Blood Analysis programs and Check-up

Personal Service with Friendly, Dedicated Professional Patient Care Managers

Scientific Collaborations with Renowned Academic Institutions

Scientific Data Acquisition and Publishing

Travel Visa and Concierge Service

Code of Operation, Integrity, Ethical and Legal Framework

Anova IRM works strictly within the German and European legal framework in an ongoing dialog with the German Governement’s regulatory bodies. Use and strategy of any therapy is decided on an individual basis and explicit informed consent with the patient. The Anova clinic operates in full ISO9001 compliance.

Regierungspräsidium Hessen: Darmstadt regional authority
Paul Ehrlich Institute: Federal regulatory authority
European Medicines Agency: Laying down Community procedures for the authorisation and supervision of medicinal products for human and veterinary use
Gesetz über den Verkehr mit Arzneimitteln (Arzneimittelgesetz - AMG): Legal framework for trafficing pharmacutical products
Good Manufacturing Practice: Laying down the principles and guidelines of good manufacturing practice in respect of medicinal products for human use and investigational medicinal products for human use
Advanced Therapy Medicinal Products: Amending Directive 2001/83/EC and Regulation (EC) No 726/2004
Good Clinical Practice: Laying down principles and detailed guidelines for good clinical practice as regards investigational medicinal products for human use. Also regulating clinical trials for human use.
ISO9001: Defining fundamentals of quality systems, among others for medical institutes.
Medicinal Product for human use: Amending Directive 2001/83/EC on the Community code
Medical Devices: Council Directive regulating medical devices

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